WebMutations in either TSC2 or the related TSC1 (hamartin) gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors (2). Tuberin is directly phosphorylated at Thr1462 by Akt/PKB (3). Phosphorylation at Thr1462 and Tyr1571 regulates tuberin-hamartin ... WebAddgene Alerts. Receive email alerts when new plasmids with this gene become available. Log in to subscribe to Addgene Alerts. Description TSC complex subunit 2. Also known as LAM, PPP1R160, TSC4. Species Homo sapiens. Entrez ID 7249. MGC ID BC150300.
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WebNov 19, 2015 · In a German woman with FAP3 and multiple additional extracolonic neoplasms, Rivera et al. (2015) identified compound heterozygous mutations in the NTHL1 gene ( 602656.0001 and 602656.0002 ). Six different tumors from the proband were found to carry somatic mutations in driver genes, such as FGFR3 ( 134934 ). WebBackground. Tuberin is a product of the TSC2 tumor suppressor gene and an important regulator of cell proliferation and tumor development (1). Mutations in either TSC2 or the related TSC1 (hamartin) gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant ... how much oxygen is left on earth
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WebUse Trimble Installation Manager for Windows to: Install and update supported Trimble® software to: a field controller connected to an office computer or tablet running Trimble Installation Manager WebApr 4, 2024 · Objective: To describe a child meeting diagnostic criteria for tuberous sclerosis complex (TSC) carrying a pathogenic somatic variant in RHEB , but no pathogenic variants in the two known TSC genes, TSC1 or TSC2 . Methods: We present the clinical and imaging findings in a child presenting with drug-resistant focal seizures and multiple cortical … WebNov 24, 2009 · An autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. It is characterized by hamartomas (benign overgrowths predominantly of a cell or tissue type that occurs normally in the organ) and hamartias (developmental abnormalities of tissue combination). Clinical manifestations include … how much oxygen is in the ocean