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WebFeb 8, 2008 · To determine the patterns of H1 and PARP-1 localization across selected regions of the human genome, we performed chromatin immunoprecipitation (ChIP) in MCF-7 breast cancer cells using antibodies specific to PARP-1 and H1 (7, 8), coupled with hybridization of the enriched genomic DNA to custom microarrays (i.e., ChIP-chip) ().Each …
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