Concanamycin a wikipedia
WebConcanamycin C39H64O10 CID 156963309 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ... Webconcanamycin (3)5) contain the as yet unidentified, glycerol-based "unusual C2 chain extender unit", also referred to as a "glycolate" unit.23) Such C2 units, all bearing an. α-methoxy group of ...
Concanamycin a wikipedia
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WebMuroi et al (1993) Folimycin (Concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitus virus before arrival to the golgi apparatus. Cell Struct.Function. 18 139. Nishihara et al (1995) Specific inhibitors of vacuolar type H + -ATPases induce apoptotic cell death. Webtive carbene is generated from this concanamycin deriv-ative, resulting in the formation of a covalent bond to the enzyme. In addition, the radioactive tracer 125I makes the detection …
WebConcanamycin A (English) KEGG ID. C15761. 1 reference. stated in. ChEBI. ChEBI ID. 73167. language of work or name. English. title. concanamycin A (English) retrieved. 7 … Webconcanamycin (plural concanamycins) Any of a group of antibiotics extracted from the gut of the tobacco hornworm Retrieved from " …
WebConcanamycin A is a specific inhibitor of V-type (vacuolar) H + -ATPase that displays > 2000-fold selectivity over other H + -ATPases (IC 50 values are 9.2, > 20000, > 20000 and > 20000 nM for yeast V-type, F-type, P-type H + -ATPases and porcine P-type Na + ,K + -ATPase respectively). Blocks cell surface expression of virus envelope ... WebJun 14, 2024 · Concanamycin A. This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon. Concanamycin A is an H+-ATPase …
WebSep 8, 2024 · Concanamycin A counteracted Nef from diverse clades of HIV targeting multiple allotypes of MHC-I, indicating the potential for broad therapeutic utility. Abstract …
WebConcanamycin A is a plecomacrolide antibiotic that has been found in Streptomyces. 1 It is active against S. cerevisiae, S. sake, A. citri, P. citrinum, and P. oryzae (MICs = <0.39, <0.39, <0.39, 1.56, and 25 μg/ml, respectively). Concanamycin A inhibits vacuolar H + -ATPase (V-ATPase; EC 50 = ~2.1-2.3 μM). 2 It also decreases perforin levels ... fehily timoney corkWebConcanamycin a C46H75NO14 CID 6438151 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and … fehily timoney and company dublinWebATPase) exhibited high sensitivity to concanamycin A, with an IC50 of 0.002 x 10-3 µmol/mg. Concanamycin A has 20 times the inhibitory effect on the V-type ATPase compared to bafilomycin A1.2 Its inhibition of vacuolar type H+ ATPase has been studied,3 and compared with the effects of bafilomycin in inducing apoptotic cell death. The family of define the term net profitWebMay 15, 1996 · Perforin- and Fas-based cytolytic pathways are two major mechanisms of cell-mediated cytotoxicity. Recently, we have shown that an inhibitor of vacuolar type H+ … define the term natural resourcesWebV-type ATPases are inhibited by the plecomacrolides bafilomycin and concanamycin, which exert their inhibitory potential at nanomolar concentrations. In addition, some P … define the term networkingWebAug 4, 2024 · Two concanamycin derivatives obtained from the solid fermentation have been determined by analysis of the infrared, high-resolution electrospray ionization mass spectrometry, 1D and 2D NMR spectra as well as by comparison with literature data. Of the two derivatives, one is a new compound, named concanamycin H, and the other is the … fehily timoney \\u0026 coWebConcanamycin A will also affect both PRF1 and GZMB release. Irrespective of the mechanism underlying this effect, these results indicate that GZMB may exert the same … define the term network protocol